## Abstract

A class of n-dimensional ODEs with up to n feedbacks from the n’th variable is analysed. The feedbacks are represented by non-specific, bounded, non-negative C1 functions. The main result is the formulation and proof of an easily applicable criterion for existence of a globally stable fixed point of the system. The proof relies on the contraction mapping theorem. Applications of this type of systems are numerous in biology, e.g., models of the hypothalamic-pituitary-adrenal axis and testosterone secretion. Some results important for modelling are: 1) Existence of an attractive trapping region. This is a bounded set with non-negative elements where solutions cannot escape. All

solutions are shown to converge to a “minimal” trapping region. 2) At least one fixed point exists. 3) Sufficient criteria for a unique fixed point are formulated. One case where this is fulfilled is when the feedbacks are negative.

solutions are shown to converge to a “minimal” trapping region. 2) At least one fixed point exists. 3) Sufficient criteria for a unique fixed point are formulated. One case where this is fulfilled is when the feedbacks are negative.

Original language | English |
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Journal | Advances in Pure Mathematics |

Volume | 6 |

Issue number | 5 |

Pages (from-to) | 393-407 |

Number of pages | 15 |

DOIs | |

Publication status | Published - 2016 |